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Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF.

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Author

Summary, in English

Caveolae are invaginations in the plasma membrane that depend on caveolins and cavins for maturation. Here, we investigated the pulmonary phenotype in mice lacking cavin-1. Bright field and electron-microscopy showed that the cavin-1-deficient mice lacked caveolae in the lung, had an increased lung tissue density, and exhibited hypertrophic remodeling of pulmonary arteries. The right ventricle of the heart moreover had an increased mass and the right ventricular pressure was elevated. A microarray analysis revealed upregulation of Arg1 and downregulation of Ddah1, molecules whose altered expression has previously been associated with pulmonary arterial hypertension. Taken together, this work demonstrates vascular remodeling and increased pulmonary blood pressure in cavin-1 deficient mice and associates this phenotype with altered expression of Arg1 and Ddah1.

Publishing year

2013

Language

English

Pages

00008-00008

Publication/Series

Physiological Reports

Volume

1

Issue

1

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Physiology

Status

Published

Research group

  • Cellular Biomechanics
  • Airway Inflammation and Immunology

ISBN/ISSN/Other

  • ISSN: 2051-817X