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Tridemethylisovelleral, a potent cytotoxic agent

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Author

  • Isabelle Aujard
  • Daniel Röme
  • Erwan Arzel
  • Martin H Johansson
  • D de Vos
  • Olov Sterner

Summary, in English

The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaidehyde system but lacking the three methyl groups, is reported. The cytotoxicity of tridemethylisovelleral toward several tumor cell lines was found to be comparable with those of established antitumor drugs, and significantly higher than that of isovelleral. (c) 2005 Elsevier Ltd. All rights reserved.

Publishing year

2005

Language

English

Pages

6145-6150

Publication/Series

Bioorganic & Medicinal Chemistry

Volume

13

Issue

22

Document type

Journal article

Publisher

Elsevier

Topic

  • Organic Chemistry

Status

Published

ISBN/ISSN/Other

  • ISSN: 0968-0896