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Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer

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Author

  • EH Mahlamaki
  • M Barlund
  • M Tanner
  • Ludmila Gorunova
  • Mattias Höglund
  • R Karhu
  • A Kallioniemi

Summary, in English

Genetic changes involved in the development and progression of pancreatic cancer are still partly unknown, despite the progress in recent years. In this study, comparative genomic hybridization analysis in 31 pancreatic cancer cell lines showed that chromosome arms 8q, 11q, 17q, and 20q are frequently gained in this tumor type. Copy number analysis of selected genes from these chromosome arms by fluorescence in situ hybridization showed amplification of the MYC oncogene in 54% of the cell lines, whereas CCNDI was amplified in 28%. In the 17q arm, the ERB82 oncogene was amplified in 20% of the cell lines, TBX2 in 50%, and BIRC5 in 58%, indicating increased involvement toward the q telonnere of chromosome 17. In the 20q arm, the amplification frequencies varied from 32% to 83%, with the CTSZ gene at 20q 13 being most frequently affected. These results illustrate that amplification of genes from the 8q, 11q, 17q, and 20q chromosome arms is common in pancreatic cancer.

Publishing year

2002

Language

English

Pages

353-358

Publication/Series

Genes, Chromosomes and Cancer

Volume

35

Issue

4

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Medical Genetics

Status

Published

ISBN/ISSN/Other

  • ISSN: 1045-2257