Elevated level of wnt5a protein in localized prostate cancer tissue is associated with better outcome.

Summary, in English

Wnt5a is a non-canonical secreted glycoprotein of the Wnt family that plays an important role in cancer development and progression. Previous studies report that Wnt5a is upregulated in prostate cancer and suggested that Wnt5a affects migration and invasion of prostate tumor cell. This study aimed to evaluate the prognostic value of Wnt5a protein expression in prostate cancer tissue and its potential to predict outcome after radical prostatectomy in patients with localized prostate cancer.

• Author: Azharuddin Sajid Syed Khaja; Leszek Helczynski; Anders Edsjö; Roy Ehrnström; Anna Lindgren; David Ulmert; Tommy Andersson; Anders Bjartell
• Department/s: Pathology, Malmö; Urological cancer, Malmö; Department of Translational Medicine; Mathematical Statistics; Clinical Chemistry, Malmö; Experimental Pathology, Malmö; EpiHealth: Epidemiology for Health; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2011
• Language: English
• Publication/Series: PLoS ONE
• Volume: 6
• Issue: 10
• Full text: - 656 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/22039506?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0026539
• Document type: Journal article
• Publisher: Public Library of Science (PLoS)
• Topic: Cancer and Oncology
• Status: Published
• Research group: Pathology, Malmö; Urological cancer, Malmö; Clinical Chemistry, Malmö; Experimental Pathology, Malmö
• ISBN/ISSN/Other: ISSN: 1932-6203