Molecular analysis of the O alleles at the blood group ABO locus in populations of different ethnic origin reveals novel crossing-over events and point mutations

Summary, in English

The blood group ABO genotypes of 138 group O individuals with three different ethnic origins in Brazil were determined, including Whites, Blacks and Amerindians. Several previously undescribed O alleles were found, predominantly in the Black group, in which about a third of the samples did not conform to previously known O allele structures. It has been well documented for the first time that some new alleles can arise from crossing-over events between known alleles in the ABO system. This was made possible by both restriction endonuclease analysis and direct sequencing of exons 3-7 in the ABO gene. The anticipated relatively high frequency of some of these new alleles in certain populations, necessitates great care when interpreting results from existing genotype screening methods.

• Author: Martin L Olsson; Joao F Guerreiro; Marco A Zago; Alan Chester
• Department/s: Division of Hematology and Transfusion Medicine; Transfusion Medicine
• Publishing year: 1997
• Language: English
• Pages: 779-782
• Publication/Series: Biochemical and Biophysical Research Communications
• Volume: 234
• Issue: 3
• Links: http://dx.doi.org/10.1006/bbrc.1997.6713
• Document type: Journal article
• Publisher: Elsevier
• Topic: Biological Sciences
• Status: Published
• Research group: Transfusion Medicine
• ISBN/ISSN/Other: ISSN: 1090-2104