Infiltration of CD3(+) and CD68(+) cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.

Summary, in English

Urothelial carcinoma (UC) aggressiveness is determined by tumor inherent molecular characteristics, such as molecular subtypes, as well as by host reactions directed toward the tumor. Cell types responsible for the host׳s response include tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). The aim of the present investigation was to explore the immunological response in relation to UC molecular subtypes and to evaluate the prognostic effect of TIL and TAM counts in tissue sections from muscle-invasive (MI) tumors.

• Author: Gottfrid Sjödahl; Kristina Lövgren; Martin Lauss; Gunilla Chebil; Oliver Hultman Patschan; Sigurdur Gudjonsson; Wiking Månsson; Mårten Fernö; Karin Leandersson; David Lindgren; Fredrik Liedberg; Mattias Höglund
• Department/s: Urothelial Cancer Genomics; Urological research, Malmö; Breastcancer-genetics; Urology; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Cancer Immunology, Malmö; Division of Translational Cancer Research
• Publishing year: 2014
• Language: English
• Pages: 791-797
• Publication/Series: Urologic Oncology
• Volume: 32
• Issue: 6
• Links: http://www.ncbi.nlm.nih.gov/pubmed/24794251?dopt=Abstract; http://dx.doi.org/10.1016/j.urolonc.2014.02.007
• Document type: Journal article
• Publisher: Elsevier
• Topic: Urology and Nephrology; Cancer and Oncology
• Status: Published
• Research group: Urothelial Cancer Genomics; Urological research, Malmö; Urology; Cancer Immunology, Malmö
• ISBN/ISSN/Other: ISSN: 1873-2496