Dyskinesias following neural transplantation in Parkinson's disease.

Summary, in English

Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by (18)F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopaminergic neurons.

• Author: Peter Hagell; Paola Piccini; Anders Björklund; Patrik Brundin; Stig Rehncrona; Håkan Widner; Lesley Crabb; Nicola Pavese; Wolfgang H Oertel; Niall Quinn; David J Brooks; Olle Lindvall
• Department/s: Department of Health Sciences; Neurobiology; Department of Experimental Medical Science; Neurosurgery; Neurology, Lund; Wallenberg Neuroscience Centre, Lund
• Publishing year: 2002
• Language: English
• Pages: 627-628
• Publication/Series: Nature Neuroscience
• Volume: 5
• Issue: 7
• Full text: - 77 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12042822&dopt=Abstract; http://dx.doi.org/10.1038/nn863
• Document type: Journal article
• Publisher: Nature Publishing Group
• Topic: Neurosciences
• Keywords: Parkinson Disease : therapy; Parkinson Disease : radionuclide imaging; Neurons : transplantation; Middle Age; Mesencephalon : transplantation; Mesencephalon : embryology; Mesencephalon : cytology; Hyperkinesis : etiology; Hyperkinesis : diagnosis; Human; Dystonia : etiology; Dystonia : diagnosis; Dyskinesias : etiology; Dyskinesias : diagnosis; Disease Progression; Cultured; Cells; Brain Tissue Transplantation : adverse effects; Cell Division : physiology; Postoperative Complications : diagnosis; Postoperative Complications : etiology; Putamen : physiopathology; Putamen : radionuclide imaging; Retrospective Studies; Support; Non-U.S. Gov't; Time Factors
• Status: Published
• Research group: Neurobiology
• ISBN/ISSN/Other: ISSN: 1546-1726