Photocoagulation of human retinal pigment epithelium in vitro: unravelling the effects on ARPE-19 by transcriptomics and proteomics.

Summary, in English

Despite the extensive use of retinal photocoagulation for ischaemia and vascular leakage in retinal vascular disease, the molecular mechanisms behind its clinical beneficial effects are still poorly understood. One important target of laser irradiation is the retinal pigment epithelium (RPE). In this study, we aimed at identifying the isolated effects of photocoagulation of RPE at both the mRNA and protein expression levels.

• Author: Poya T-Khani; Carolina de la Torre; Francesc Canals; Hedvig Bennet; Rafael Simo; Cristina Hernandez; Malin Fex; Carl-David Agardh; Ola Hansson; Elisabet Agardh
• Department/s: Ophthalmology (Malmö); Celiac Disease and Diabetes Unit; Department of Clinical Sciences, Malmö; EXODIAB: Excellence of Diabetes Research in Sweden
• Publishing year: 2015
• Language: English
• Pages: 348-354
• Publication/Series: Acta Ophthalmologica
• Volume: 93
• Issue: 4
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25604382?dopt=Abstract; http://dx.doi.org/10.1111/aos.12649
• Document type: Journal article
• Publisher: Wiley-Blackwell
• Topic: Ophthalmology
• Status: Published
• Research group: Ophthalmology (Malmö); Celiac Disease and Diabetes Unit
• ISBN/ISSN/Other: ISSN: 1755-3768