Integrating disease knowledge and technology to deliver protein targets and biomarkers into drug discovery projects

Summary, in English

Biomarker discovery is dependent upon two disciplines: the field of clinical bioanalysis linked to disease aetiology and the application of high level technology platforms for identifying proteins/peptides in complex samples. However, diagnostic biomarker measurements require certain definitions of context that can only be achieved by combining protein science with clinical science. The evaluation of biomarkers requires careful attention to match (1) a specific biological question with (2) the appropriate clinical sample and (3) high resolution technology systems which link protein identities to clinical informatics.

• Author: Thomas E. Fehniger; Thomas Laurell; György Marko-Varga
• Department/s: Department of Biomedical Engineering; Centre for Analysis and Synthesis
• Publishing year: 2005
• Language: English
• Pages: 345-351
• Publication/Series: Drug Discovery Today: Technologies
• Volume: 2
• Issue: 4
• Links: http://dx.doi.org/10.1016/j.ddtec.2005.11.005
• Document type: Journal article
• Publisher: Elsevier
• Topic: Analytical Chemistry; Medical Engineering
• Status: Published
• ISBN/ISSN/Other: ISSN: 1740-6749