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Cervical cytology biobanking in Europe

På svenska

Author

  • Marc Arbyn
  • Evert-Ben Van Veen
  • Kristin Andersson
  • Johannes Bogers
  • Gaelle Boulet
  • Christine Bergeron
  • Magnus von Knebel-Doeberitz
  • Joakim Dillner

Summary, in English

A cervical cytology biobank (CCB) is an extension of current cytopathology laboratory practice consisting in the systematic storage of Pap smears or liquid-based cytology samples from women participating in cervical cancer screening with the explicit purpose to facilitate future scientific research and quality audit of preventive services. A CCB should use an internationally agreed uniform cytology terminology, be integrated in a national or regional screening registry, and be linked to other registries (histology, cancer, vaccination). Legal and ethical principles concerning personal integrity and data safety must be respected strictly. Biobank-based studies require approval of ethical review boards. A CCB is an almost inexhaustible resource for fundamental and applied biological research. In particular, it can contribute to answering questions on the natural history of HPV infection and HPV-induced lesions and cancers, screening effectiveness, exploration of new biomarkers, and surveillance of the short- and long-term effects of the introduction of HPV vaccination. To understand the limitations of CCB, more studies are needed on the quality of samples in relation to sample type, storage procedures, and duration of storage.

Department/s

Publishing year

2010

Language

English

Pages

117-125

Publication/Series

International Journal of Biological Markers

Volume

25

Issue

3

Document type

Journal article

Publisher

Wichtig Editore

Topic

  • Microbiology in the medical area

Keywords

  • papillomavirus
  • Human
  • Molecular markers
  • Biobank
  • Cervical cancer
  • Cervical cytology

Status

Published

Research group

  • Epidemiology
  • Clinical Microbiology, Malmö

ISBN/ISSN/Other

  • ISSN: 0393-6155