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Nontypeable Haemophilus influenzae as a Pathogen in Children.

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Author

  • Timothy Murphy
  • Howard Faden
  • Lauren Bakaletz
  • Jennelle Kyd
  • Arne Forsgren
  • José Campos
  • Mumtaz Virji
  • Stephen Pelton

Summary, in English

Nontypeable Haemophilus influenzae is a significant pathogen in children, causing otitis media, sinusitis, conjunctivitis, pneumonia, and occasionally invasive infections. H. influenzae type b conjugate vaccines have no effect on infections caused by nontypeable strains because nontypeable strains are nonencapsulated. Approximately, one-third of episodes of otitis media are caused by nontypeable H. influenzae and the bacterium is the most common cause of recurrent otitis media. Recent progress in elucidating molecular mechanisms of pathogenesis, understanding the role of biofilms in otitis media and an increasing understanding of immune responses have potential for development of novel strategies to improve prevention and treatment of otitis media caused by nontypeable H. influenzae. Feasibility of vaccination for prevention of otitis media due to nontypeable H. influenzae was recently demonstrated in a clinical trial with a vaccine that included the surface virulence factor, protein D.

Publishing year

2009

Language

English

Pages

43-48

Publication/Series

Pediatric Infectious Disease Journal

Volume

28

Issue

1

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Microbiology in the medical area

Status

Published

Research group

  • Clinical Microbiology, Malmö

ISBN/ISSN/Other

  • ISSN: 1532-0987