Cystatin C modulates cerebral beta-amyloidosis

Summary, in English

The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.

• Author: Stephan A. Kaeser; Martin C. Herzig; Janaky Coomaraswamy; Ellen Kilger; Maj-Linda Selenica; David T. Winkler; Matthias Staufenbiel; Efrat Levy; Anders Grubb; Mathias Jucker
• Department/s: Division of Clinical Chemistry and Pharmacology
• Publishing year: 2007
• Language: English
• Pages: 1437-1439
• Publication/Series: Nature Genetics
• Volume: 39
• Issue: 12
• Links: http://www.ncbi.nlm.nih.gov/pubmed/18026102; http://www.hih-tuebingen.de/fileadmin/files/Presse/Dokumente/ng.2007.23.pdf; http://www.nature.com/ng/journal/v39/n12/full/ng.2007.23.html; http://dx.doi.org/10.1038/ng.2007.23
• Document type: Journal article
• Publisher: Nature Publishing Group
• Topic: Pharmacology and Toxicology; Medicinal Chemistry
• Status: Published
• ISBN/ISSN/Other: ISSN: 1546-1718