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Cefotetan-induced immune hemolytic anemia following prophylaxis for cesarean delivery

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Author

Summary, in English

Second- and third-generation cephalosporins, notably cefotetan, are increasingly implicated in severe, sometimes fatal immunemediated hemolytic anemia. We describe a 26-year-old woman who developed severe hemolytic anemia 2 weeks after receiving a single prophylactic dose of cefotetan during cesarean delivery. The patient's DAT was weakly reactive for IgG and her serum reacted with cefotetan-coated RBCs. The antibody had a titer of 4,096 by antiglobulin testing. The patient required treatment with two units of PRBCs and experienced gradual resolution of hemolysis. Our case emphasizes the need for increased awareness of delayed onset hemolytic anemia following prophylactic use of cefotetan.

Publishing year

2004

Language

English

Pages

63-66

Publication/Series

Immunohematology

Volume

20

Issue

1

Document type

Journal article

Publisher

American Red Cross

Topic

  • Hematology

Status

Published

ISBN/ISSN/Other

  • ISSN: 0894-203X