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Hexahydrophthalic acid in urine as an index of exposure to hexahydrophthalic anhydride

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Author

  • Bo A Jönsson
  • Hans Welinder
  • Gunnar Skarping

Summary, in English

Post-shift and next-morning urine was sampled from workers exposed to hexahydrophtalic anhydride (HHPA), an epoxy hardener, sensitising at low exposure levels. Exposure levels of HHPA in air (gas chromatography, GC) in the range of 30-270 micrograms/m3 corresponded to urinary concentrations of 0.9-2.8 mumol hexahydrophthalic acid (HHP acid; GC-mass spectrometry)/mmol creatinine. In the morning samples the concentrations were less than 0.04-0.3 mumol HHP acid/mmol creatinine. In unexposed controls, the level was less than 0.1 mumol/mmol creatinine. A correlation was found between the time-weighted levels of HHPA in air and HHP acid in the post-shift urine (rs = 0.93; P less than 0.023), indicating that the determination of HHP acid in urine is suitable for biologic monitoring of HHPA exposure.

Publishing year

1991

Language

English

Pages

77-79

Publication/Series

International Archives of Occupational and Environmental Health

Volume

63

Issue

1

Document type

Journal article

Publisher

Springer

Topic

  • Environmental Health and Occupational Health

Keywords

  • Epoxy resin
  • Hexahydrophthalic anhydride
  • Hexahydrophthalic acid
  • Urinary excretion
  • Biological monitoring

Status

Published

ISBN/ISSN/Other

  • ISSN: 1432-1246