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Chiral recognition of Nα-protected amino acids and derivatives in molecularly imprinted polymers.

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Author

Summary, in English

Highly crosslinked synthetic polymers, selective for various Nα-protected amino acids and derivatives, were prepared by non-covalent molecular imprinting. Methacrylic acid and ethylene glycol dimethacrylate were copolymerized in the presence of the print molecules, which were subsequently extracted from the polymers. The recognition of the polymers for the print molecules and molecules of similar structures was investigated by using the polymers as stationary phases in HPLC. The functional groups of the print molecules interact via hydrogen bonds with the positioned carboxyls of the polymer. It was shown that the Nα-protecting group, the Cα-protecting group and the amino acid side chain are also recognized by the binding sites in the polymer.

Publishing year

1994

Language

English

Pages

603-606

Publication/Series

International Journal of Peptide and Protein Research

Volume

44

Issue

6

Document type

Journal article

Publisher

Munksgaard Forlag

Topic

  • Biochemistry and Molecular Biology

Status

Published

Research group

  • Nanomedicine and Biomaterials

ISBN/ISSN/Other

  • ISSN: 0367-8377