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A Synthesis Method for Automatic Handling of Inter-patient Variability in Closed-loop Anesthesia

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Author

  • Kristian Soltesz
  • Klaske van Heusden
  • Martin Hast
  • J. Mark Ansermino
  • Guy A. Dumont

Summary, in English

This paper presents a convex-optimization-based technique to obtain parameters for a PID feedback controller, used to control the infusion rate of the anesthetic drug propofol. The controller design is based on a set of identified patient models, relating propofol infusion to an EEG-based conciousness index. The main contribution lies in the method automatically taking inter-patient variability into account, i.e., it guarantees robustness (sensitivity peak) and performance (disturbance rejection) over a set of patient models, without the need for manual intervention. The method is demonstrated using a clinically relevant design example. A controller designed using the proposed method is currently scheduled for clinical evaluation.

Publishing year

2016

Language

English

Pages

4877-4882

Publication/Series

Proceedings of the 2016 American Control Conference

Document type

Conference paper

Publisher

IEEE - Institute of Electrical and Electronics Engineers Inc.

Topic

  • Other Medical Engineering
  • Control Engineering

Conference name

American Control Conference, 2016

Conference date

2016-07-06 - 2016-07-08

Conference place

Boston, United States

Status

Published

Project

  • Anesthesia in Closed Loop

Research group

  • LCCC
  • ELLIIT

ISBN/ISSN/Other

  • ISBN: 978-1-4673-8682-1