The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Distinction of isolated tumour cells and micrometastasis in lymph nodes of breast cancer patients according to the new Tumour Node Metastasis (TNM) definitions

På svenska

Author

  • Gabor Cserni
  • Isabel Amendoeira
  • Simonetta Bianchi
  • Ewa Chmielik
  • James DeGaetano
  • Daniel Faverly
  • Paulo Figueiredo
  • Maria P. Foschini
  • Dorthe Grabau
  • Jocelyne Jacquemier
  • Handan Kaya
  • Janina Kulka
  • Manuela Lacerda
  • Inta Liepniece-Karele
  • Jose Martinez Penuela
  • Cecily Quinn
  • Peter Regitnig
  • Angelika Reiner-Concin
  • Anna Sapino
  • Paul J. van Diest
  • Zsuzsanna Varga
  • Vania Vezzosi
  • Jelle Wesseling
  • Vasiliki Zolota
  • Enrique Zozaya
  • Clive A. Wells
Show all

Summary, in English

Isolated tumour cells and micrometastases represent two different staging categories and are often dealt with differently when identified in sentinel lymph nodes of breast cancer patients. The reproducibility of these categories was found to be suboptimal in several studies. The new edition of the TNM (Tumour Node Metastasis) is expected to improve the reproducibility of these categories. Fifty cases of possible low-volume nodal involvement were represented by one to four digital images and were analysed by members of the European Working Group for Breast Screening Pathology (EWGBSP). The kappa value for interobserver agreement of the pN (TNM) staging categories and of the isolated tumour cells category were 0.55 and 0.56 reflecting moderate reproducibility, and the kappa of the micrometastatic category (0.62) reflected substantial reproducibility. This is an improvement over the results gained on the basis of the previous edition of the TNM. Maximal adherence to the category definitions supplemented by explanatory texts in the staging manual should result in more homogeneous nodal staging of breast cancer. (C) 2010 Elsevier Ltd. All rights reserved.

Department/s

Publishing year

2011

Language

English

Pages

887-894

Publication/Series

European Journal of Cancer

Volume

47

Issue

6

Document type

Journal article

Publisher

Elsevier

Topic

  • Surgery

Keywords

  • Breast cancer
  • Isolated tumour cells
  • Isolated tumour cell cluster
  • Micrometastasis
  • Sentinel lymph node
  • TNM

Status

Published

ISBN/ISSN/Other

  • ISSN: 1879-0852