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Antileishmanial metabolites from Trixis antimenorrhoea

På svenska

Author

  • Eliana Maldonado
  • Efrain Salamanca
  • Alberto Gimenez
  • Gloria Saavedra
  • Olov Sterner

Summary, in English

An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 mu g/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

Publishing year

2014

Language

English

Pages

281-286

Publication/Series

Phytochemistry Letters

Volume

10

Document type

Journal article

Publisher

Elsevier

Topic

  • Chemical Sciences

Keywords

  • Trixis antimenorrhoea
  • Nortrixane
  • Trixanolide
  • Antileishmanial
  • activity
  • Structural elucidation

Status

Published

ISBN/ISSN/Other

  • ISSN: 1874-3900