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The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length

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Author

  • Mark M. Iles
  • D. Timothy Bishop
  • John C. Taylor
  • Nicholas K. Hayward
  • Myriam Brossard
  • Anne E. Cust
  • Alison M. Dunning
  • Jeffrey E. Lee
  • Eric K. Moses
  • Lars A. Akslen
  • Per A. Andresen
  • Marie-Francoise Avril
  • Esther Azizi
  • Giovanna Bianchi Scarra
  • Kevin M. Brown
  • Tadeusz Debniak
  • David E. Elder
  • Eitan Friedman
  • Paola Ghiorzo
  • Elizabeth M. Gillanders
  • Alisa M. Goldstein
  • Nelleke A. Gruis
  • Johan Hansson
  • Mark Harland
  • Per Helsing
  • Marko Hocevar
  • Veronica Hoiom
  • Christian Ingvar
  • Peter A. Kanetsky
  • Maria Teresa Landi
  • Julie Lang
  • G. Mark Lathrop
  • Jan Lubinski
  • Rona M. Mackie
  • Nicholas G. Martin
  • Anders Molven
  • Grant W. Montgomery
  • Srdjan Novakovic
  • Håkan Olsson
  • Susana Puig
  • Joan Anton Puig-Butille
  • Graham L. Radford-Smith
  • Juliette Randerson-Moor
  • Nienke van der Stoep
  • Remco van Doorn
  • David C. Whiteman
  • Stuart MacGregor
  • Karen A. Pooley
  • Sarah V. Ward
  • Graham J. Mann
  • Christopher I. Amos
  • Paul D. P. Pharoah
  • Florence Demenais
  • Matthew H. Law
  • Julia A. Newton Bishop
  • Jennifer H. Barrett
Show all

Summary, in English

Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11 108 case patients and 13 933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.

Department/s

Publishing year

2014

Language

English

Pages

267-267

Publication/Series

Journal of the National Cancer Institute

Volume

106

Issue

10

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Cancer and Oncology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1460-2105