Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls.

Summary, in English

Although many pediatric B-cell lymphoma patients are being cured today, much is still unknown about the pathogenesis of this disease. Protein tyrosine phosphatases are involved in the control of survival, growth, and differentiation of cells. The authors have analyzed 26 pediatric B-cell lymphoma cases for the expression of a panel of phosphatases and report a statistically significant lower expression intensity of PTEN and HePTP and higher nuclear SHP2 expression in B-cell lymphoma cases compared to lymphoid tissue. Knowledge about the expression of key regulatory proteins in pediatric B-cell lymphomas is necessary for revealing the complex molecular background of this disease.

• Author: Marie Fridberg; Sofia Kjellström; Lola Anagnostaki; Ingela Skogvall; Tomas Mustelin; Thomas Wiebe; Jenny L Persson; Michael Dictor; Anette Gjörloff Wingren
• Department/s: Department of Translational Medicine; Tumor microenvironment; Section V; Experimental Cancer Research, Malmö
• Publishing year: 2008
• Language: English
• Pages: 528-540
• Publication/Series: Pediatric Hematology & Oncology
• Volume: 25
• Issue: 6
• Links: http://www.ncbi.nlm.nih.gov/pubmed/18728972?dopt=Abstract; http://dx.doi.org/10.1080/08880010802237054
• Document type: Journal article
• Publisher: Hemisphere Pub. Corp.
• Topic: Cancer and Oncology
• Status: Published
• Research group: Experimental Cancer Research, Malmö
• ISBN/ISSN/Other: ISSN: 1521-0669