Emerging restorative treatments for Parkinson's disease.
Author
Summary, in English
Several exciting approaches for restorative therapy in Parkinson's disease have emerged over the past two decades. This review initially describes experimental and clinical data regarding growth factor administration. We focus on glial cell line-derived neurotrophic factor (GDNF), particularly its role in neuroprotection and in regeneration in Parkinson's disease. Thereafter, we discuss the challenges currently facing cell transplantation in Parkinson's disease and briefly consider the possibility to continue testing intrastriatal transplantation of fetal dopaminergic progenitors clinically. We also give a more detailed overview of the developmental biology of dopaminergic neurons and the potential of certain stem cells, i.e. neural and embryonic stem cells, to differentiate into dopaminergic neurons. Finally, we discuss adult neurogenesis as a potential tool for restoring lost dopamine neurons in patients suffering from Parkinson's disease.
Department/s
Publishing year
2008
Language
English
Pages
407-432
Publication/Series
Progress in Neurobiology
Volume
85
Links
Document type
Journal article
Publisher
Elsevier
Topic
- Neurosciences
Status
Published
ISBN/ISSN/Other
- ISSN: 1873-5118