Biocompatibility of a polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+) for neural implants.

Summary, in English

The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+, consisting of a thiol, two allyls, an epoxy resin and two initiators), which is up to 100 times more flexible than polyimide. Since a flexible neural probe should be more biocompatible than a stiff probe, an OSTE+ probe should be more biocompatible than one composed of a more rigid material. We have investigated the toxicity of OSTE+ as well as of OSTE+ that had been incubated in water for a week (OSTE+H2O) using MTT assays with mouse L929 fibroblasts. We found that OSTE+ showed cytotoxicity, but OSTE+H2O did not. Extracts were analyzed using LC-MS and GC-MS in order to identify leaked chemicals.

• Author: Fredrik Ejserholm; John Stegmayr; Patrik Bauer; Fredrik Johansson; Lars Wallman; Martin Bengtsson; Stina Oredsson
• Department/s: Neuronano Research Center (NRC); Department of Biomedical Engineering; Functional zoology; Division of Microbiology, Immunology and Glycobiology - MIG
• Publishing year: 2015
• Language: English
• Pages: 1-10
• Publication/Series: Biomaterials research
• Volume: 19
• Issue: 19
• Full text: - 2 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26396744?dopt=Abstract; http://dx.doi.org/10.1186/s40824-015-0041-3
• Document type: Journal article
• Publisher: BioMed Central (BMC)
• Topic: Medical Biotechnology
• Status: Published
• Research group: Neuronano Research Center (NRC)
• ISBN/ISSN/Other: ISSN: 2055-7124