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Models for the Insulin Response to Intravenous Glucose

På svenska

Author

  • Per Hagander
  • Karl-Göran Tranberg
  • Jan Thorell
  • Joseph DiStefano III

Summary, in English

The Grodsky packet storage model describes many features of insulin release, but at present more or less arbitrary simplifications are necessary. The consequences of various simplifications are discussed, especially with regard to identification of parameters thought to be of importance for glucose tolerance. In particular, the insulin release dynamics of the ordinary intravenous glucose tolerance test is examined. The proposed model contains the following features: It considers arterial rather than venous blood glucose concentration as the stimulus, it takes the glucose injection time into account, and it contains a positive derivative term during the rise of the glucose concentration. When the insulin elimination-rate time constant is fixed to an a priori value, model fitting gives a clear quantification of the sensitivity of early and late insulin release to glucose.

Publishing year

1978-11

Language

English

Pages

15-29

Publication/Series

Mathematical Biosciences

Volume

42

Document type

Journal article

Publisher

Elsevier

Topic

  • Control Engineering
  • Other Health Sciences

Status

Published

ISBN/ISSN/Other

  • ISSN: 0025-5564