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Association of HLA-DQ5 and HLA-DR1 with sensitization to organic acidanhydrides

På svenska

Author

  • MG Jones
  • Jörn Nielsen
  • J Welch
  • J Harris
  • Hans Welinder
  • Inger Bensryd
  • Staffan Skerfving
  • K Welsh
  • KM Venables
  • AN Taylor

Summary, in English

Background Organic acid anhydrides are low molecular weight industrial chemicals, able to cause rhinoconjunctivitis and asthma associated with specific IgE against hapten-carrier protein conjugate. Only a proportion of exposed workers develop IgE-associated allergy to acid anhydrides. Objective We determined whether genetic susceptibility, in particular, HLA Class II alleles may be a risk factor. Methods We undertook HLA typing in 52 cases who had confirmed specific IgE and in 73 referents matched on site, age and duration of acid anhydride exposure identified in cross-sectional studies of workers exposed to hexahydrophthalic (HHPA), methylhexahydrophthalic (MHHPA) and methyltetrahydrophthalic (MTHPA) anhydrides. Results The linked alleles DQ5 (odds ratio [OR]=4.3; 95% confidence interval [95% CI]=1.7, 11) and DR1 (OR 3.0; 95% CI 1.2, 11) were more prevalent in cases than in referents. Within DQ5, DQB1*0501 was particularly frequent (OR 3.0; 95% CI 1.2, 7.4). Conclusion DQB1*05 gene confers susceptibility to develop specific IgE antibodies against HHPA, MHHPA and a non-significant trend with MTHPA. DQB1*0501 is protective for other low molecular chemical sensitizers (isocyanates and plicatic acid) which may indicate varying affinities for the corresponding specific class II molecules.

Publishing year

2004

Language

English

Pages

812-816

Publication/Series

Clinical and Experimental Allergy

Volume

34

Issue

5

Document type

Journal article

Publisher

Wiley

Topic

  • Respiratory Medicine and Allergy

Keywords

  • occupational allergy and asthma
  • acid anhydrides
  • HLA class II

Status

Published

ISBN/ISSN/Other

  • ISSN: 1365-2222