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Mechanisms underlying cortical resonant states: implications for levodopa-induced dyskinesia

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Author

Summary, in English

A common observation in recordings of neuronal activity from the cerebral cortex is that populations of neurons show patterns of synchronized oscillatory activity. However, it has been suggested that neuronal synchronization can, in certain pathological conditions, become excessive and possibly have a pathogenic role. In particular, aberrant oscillatory activation patterns have been implicated in conditions involving cortical dysfunction. We here review the mechanisms thought to be involved in the generation of cortical oscillations and discuss their relevance in relation to a recent finding indicating that high-frequency oscillations in the cerebral cortex have an important role in the generation of levodopa-induced dyskinesia. On the basis of these insights, it is suggested that the identification of physiological changes associated with symptoms of disease is a particularly important first step toward a more rapid development of novel treatment strategies.

Publishing year

2013

Language

English

Pages

415-429

Publication/Series

Reviews in the Neurosciences

Volume

24

Issue

4

Document type

Journal article

Publisher

Freund Publishing House Ltd

Topic

  • Neurosciences

Keywords

  • basal ganglia
  • dopamine
  • motor cortex
  • neuronal circuits
  • oscillations
  • Parkinson's disease

Status

Published

Research group

  • Integrative Neurophysiology
  • Neuronano Research Center (NRC)

ISBN/ISSN/Other

  • ISSN: 0334-1763