Reduction in glomerular pore size is not restricted to pregnant women. Evidence for a new syndrome: 'Shrunken pore syndrome'.

Summary, in English

The plasma levels of cystatin C, β2-microglobulin, beta-trace protein, retinol binding protein (RBP) and creatinine were determined in plasma samples from 111 randomly selected patients with eGFRcystatin C ≤ 60% of eGFRcreatinine and from 55 control patients with 0.9eGFRcreatinine ≤ eGFRcystatin C ≤ 1.1eGFRcreatinine (eGFRcystatin C ≈ eGFRcreatinine). The concentration ratios of cystatin C/creatinine, β2-microglobulin/creatinine, beta-trace protein/creatinine and RBP/creatinine were significantly higher in patients with eGFRcystatin C ≤ 60% of eGFRcreatinine than in patients with eGFRcystatin C ≈ eGFRcreatinine. When the patients were divided into three groups with different estimated GFR intervals (≤ 40, 40-60 and ≥ 60 mL/min/1.73m(2)) the concentration ratios of cystatin C/creatinine, β2-microglobulin/creatinine, and beta-trace protein/creatinine were significantly higher in patients with eGFRcystatin C ≤ 60% of eGFRcreatinine than in patients with eGFRcystatin C ≈ eGFRcreatinine for all GFR intervals. Similar results were obtained when the population without pregnant women was studied as well as the subpopulations of men or of non-pregnant women. Populations of pre-eclamptic women and pregnant women in the third trimester display similar results. Since the production of these four proteins with sizes similar to that of cystatin C is not co-regulated, the most likely explanation for the simultaneous increase of their creatinine-ratios in patients with eGFRcystatin C ≤ 60% of eGFRcreatinine is that their elimination by glomerular filtration is decreased. We suggest that this is due to a reduction in pore diameter of the glomerular membrane and propose the designation 'Shrunken pore syndrome' for this pathophysiological state.

• Author: Anders Grubb; Veronica Lindström; Magnus Jonsson; Sten-Erik Bäck; Tomas Åhlund; Bengt Rippe; Anders Christensson
• Department/s: Division of Clinical Chemistry and Pharmacology; Clinical Chemistry, Malmö; Nephrology; Internal Medicine - Epidemiology; Cystatin C, renal disease, amyloidosis and antibiotics; EpiHealth: Epidemiology for Health
• Publishing year: 2015
• Language: English
• Pages: 333-340
• Publication/Series: Scandinavian Journal of Clinical & Laboratory Investigation
• Volume: 75
• Issue: 4
• Full text: - 551 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25919022?dopt=Abstract; http://dx.doi.org/10.3109/00365513.2015.1025427
• Document type: Journal article
• Publisher: Informa Healthcare
• Topic: Clinical Laboratory Medicine
• Status: Published
• Project: Shrunken Pore Syndrome (SPS) - morbidity and mortality in a population with measured glomerular filtration rate (GFR)
• Research group: Clinical Chemistry, Malmö; Internal Medicine - Epidemiology; Cystatin C, renal disease, amyloidosis and antibiotics
• ISBN/ISSN/Other: ISSN: 1502-7686