microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons.

Summary, in English

New neurons, originating from the subventricular zone, are continuously integrating into neuronal circuitry in the olfactory bulb (OB). Using a transgenic sensor mouse, we found that adult-born OB interneurons express microRNA-125 (miR-125), whereas the pre-existing developmentally generated OB interneurons represent a unique population of cells in the adult brain, without miR-125 activity. Stable inhibition of miR-125 in newborn OB neurons resulted in enhanced dendritic morphogenesis, as well as in increased synaptic activation in response to odour sensory stimuli. These data demonstrate that miR-125 controls functional synaptic integration of adult-born OB interneurons. Our results also suggest that absence of an otherwise broadly expressed miRNA is a novel mechanism with which to achieve neuronal subtype specification.

• Author: Malin Åkerblom; Rebecca Petri; Rohit Sachdeva; Thies Klüssendorf; Bengt Mattsson; Bernhard Gentner; Johan Jakobsson
• Department/s: Molecular Neurogenetics; Neurobiology; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publishing year: 2014
• Language: English
• Pages: 1580-1588
• Publication/Series: Development: For advances in developmental biology and stem cells
• Volume: 141
• Issue: 7
• Links: http://www.ncbi.nlm.nih.gov/pubmed/24598163?dopt=Abstract; http://dx.doi.org/10.1242/dev.101659
• Document type: Journal article
• Publisher: The Company of Biologists Ltd
• Topic: Developmental Biology
• Status: Published
• Research group: Molecular Neurogenetics; Neurobiology
• ISBN/ISSN/Other: ISSN: 1477-9129