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The Nordic Reference Interval Project 2000: recommended reference intervals for 25 common biochemical properties

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Author

  • P Rustad
  • P Felding
  • L Franzson
  • V Kairisto
  • A Lahti
  • A Martensson
  • PH Petersen
  • Per Simonsson
  • H Steensland
  • A Uldall

Summary, in English

Each of 102 Nordic routine clinical biochemistry laboratories collected blood samples from at least 25 healthy reference individuals evenly distributed for gender and age, and analysed 25 of the most commonly requested serum/plasma components from each reference individual. A reference material ( control) consisting of a fresh frozen liquid pool of serum with values traceable to reference methods ( used as the project "calibrator'' for non-enzymes to correct reference values) was analysed together with other serum pool controls in the same series as the project samples. Analytical data, method data and data describing the reference individuals were submitted to a central database for evaluation and calculation of reference intervals intended for common use in the Nordic countries. In parallel to the main project, measurements of commonly requested haematology properties on EDTA samples were also carried out, mainly by laboratories in Finland and Sweden. Aliquots from reference samples were submitted to storage in a central bio-bank for future establishment of reference intervals for other properties. The 25 components were, in alphabetical order: alanine transaminase, albumin, alkaline phosphatase, amylase, amylase pancreatic, aspartate transaminase, bilirubins, calcium, carbamide, cholesterol, creatine kinase, creatininium, gamma-glutamyltransferase, glucose, HDL-cholesterol, iron, iron binding capacity, lactate dehydrogenase, magnesium, phosphate, potassium, protein, sodium, triglyceride and urate.

Publishing year

2004

Language

English

Pages

271-283

Publication/Series

Scandinavian Journal of Clinical & Laboratory Investigation

Volume

64

Issue

4

Document type

Journal article

Publisher

Informa Healthcare

Topic

  • Medicinal Chemistry

Keywords

  • reference sample
  • reference material
  • reference limit
  • IFCC enzyme
  • reference individual

Status

Published

Research group

  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1502-7686