The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Defining the hematopoietic stem cell niche: the chicken and the egg conundrum

På svenska

Author

  • Sofie Singbrant
  • M. Askmyr
  • L. E. Purton
  • C. R. Walkley

Summary, in English

Understanding the in vivo regulation of hematopoietic stem cells (HSCs) will be critical to identifying key factors involved in the regulation of HSC self-renewal and differentiation. The niche (microenvironment) in which HSCs reside has recently regained attention accompanied by a dramatic increase in the understanding of the cellular constituents of the bone marrow HSC niche. The use of sophisticated genetic models allowing modulation of specific lineages has demonstrated roles for mesenchymal-derived elements such as osteoblasts and adipocytes, vasculature, nerves, and a range of hematopoietic progeny of the HSC as being participants in the regulation of the bone marrow microenvironment. Whilst providing significant insight into the cellular composition of the niche, is it possible to manipulate any given cell lineage in vivo without impacting, knowingly or unknowingly, on those that remain?

Publishing year

2011

Language

English

Pages

90-1486

Publication/Series

Journal of Cellular Biochemistry

Volume

112

Issue

6

Document type

Journal article review

Publisher

Wiley-Blackwell

Topic

  • Hematology

Keywords

  • Animals
  • Bone Marrow Cells/cytology
  • Hematopoietic Stem Cells/*cytology
  • Humans
  • Mice
  • Stem Cell Niche/*cytology

Status

Published

ISBN/ISSN/Other

  • ISSN: 0730-2312