Small airway epithelial-C/EBPβ is increased in patients with advanced COPD.

Summary, in English

The expression of CCAAT/enhancer-binding protein (C/EBP)β in the small airway epithelium of COPD is unknown. C/EBPβ was assessed in peripheral lung tissue of non-smoking/smoking controls and patients with GOLD I-IV COPD by quantitative immunohistochemistry. The expression of C/EBPβ was decreased in smokers compared to never smokers. Furthermore, C/EBPβ was significantly elevated in advanced COPD vs. asymptomatic smokers, and the expression correlated to lung function decline. As C/EBPβ exerts pro-inflammatory effects in the context of cigarette smoke, the elevated C/EBPβ in advanced COPD may be an indication of a breakdown of regulatory mechanisms and excessive inflammation.

• Author: Michiko Mori; Leif Bjermer; Jonas Erjefält; Martin R Stampfli; Abraham Roos
• Department/s: Airway Inflammation and Immunology; Respiratory Medicine, Allergology, and Palliative Medicine; EpiHealth: Epidemiology for Health
• Publishing year: 2015
• Language: English
• Publication/Series: Respiratory Research
• Volume: 16
• Full text: - 788 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26511475?dopt=Abstract; http://dx.doi.org/10.1186/s12931-015-0297-0
• Document type: Journal article
• Publisher: BioMed Central (BMC)
• Topic: Respiratory Medicine and Allergy
• Status: Published
• Research group: Airway Inflammation and Immunology
• ISBN/ISSN/Other: ISSN: 1465-9921