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A potential double role of anti-Lewis X antibodies in Helicobacter pylori-associated gastroduodenal diseases

På svenska

Author

  • W. Rudnicka
  • E. Czkwianianc
  • I. Planeta-Malecka
  • M. Jurkiewicz
  • M. Wisniewska
  • T. Cieslikowski
  • B. Rozalska
  • Torkel Wadström
  • M. Chmiela

Summary, in English

In this study, we found Lewis X (Le(X)) determinants on 68% of Helicobacter pylori isolates from patients with chronic gastroduodenal diseases. Anti-Le(X) IgG were detected more frequently in the sera from dyspeptic children and adults (45 and 46%), with or without proved (culture) H. pylori infection, than in the sera from healthy individuals (14%, and 25%). In contrast, the prevalence of anti-Le(X) IgM was higher in the groups of healthy individuals than in the groups of dyspeptic patients. Moreover. anti-Le(X) monoclonal antibody of IgM class enhanced the uptake of Le(X)(+) but not Le(X)(-) H. pylori isolates by phagocytes. In the sera from some dyspeptic patients, we detected Le(X)-anti-Le(X) IgG immune complexes (Le(X) ICs). There was a great difference between children and adults as regards the presence of Le(X) ICs. The immune complexes were found in the sera from nine out of 29 (27%) H. pylori-infected and three out of eight (37%) uninfected adult dyspeptic patients. In comparison, Le(X)-anti-Le(X) IgG ICs were detected only for two out of 18 (11%) H. pylori-infected children. Le(X) ICs were not found in the sera from healthy individuals. Our results suggest that anti-Le(X) IgM may play a protective role in H. pylori infections. In contrast, anti-Le(X) IgG and particularly Le(X)-anti-Le(X) IgG ICs might contribute to the pathogenesis of chronic H. pylori infections.

Publishing year

2001

Language

English

Pages

121-125

Publication/Series

Pathogens and Disease

Volume

30

Issue

2

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Microbiology in the medical area

Keywords

  • Helicobacter pylori
  • Lewis X–anti-Lewis X immune complex
  • Lewis X

Status

Published

ISBN/ISSN/Other

  • ISSN: 2049-632X