Association of Chromosome 19 to Lung Cancer Genotypes and Phenotypes

Summary, in English

The Chromosome 19 Consortium, a part of the Chromosome-Centric Human Proteome Project (C-HPP, http://​www.​C-HPP.​org), is tasked with the understanding chromosome 19 functions at the gene and protein levels, as well as their roles in lung oncogenesis. Comparative genomic hybridization (CGH) studies revealed chromosome aberration in lung cancer subtypes, including ADC, SCC, LCC, and SCLC. The most common abnormality is 19p loss and 19q gain. Sixty-four aberrant genes identified in previous genomic studies and their encoded protein functions were further validated in the neXtProt database (http://​www.​nextprot.​org/​). Among those, the loss of tumor suppressor genes STK11, MUM1, KISS1R (19p13.3), and BRG1 (19p13.13) is associated with lung oncogenesis or remote metastasis. Gene aberrations include translocation t(15, 19) (q13, p13.1) fusion oncogene BRD4-NUT, DNA repair genes (ERCC1, ERCC2, XRCC1), TGFβ1 pathway activation genes (TGFB1, LTBP4), Dyrk1B, and potential oncogenesis protector genes such as NFkB pathway inhibition genes (NFKBIB, PPP1R13L) and EGLN2. In conclusion, neXtProt is an effective resource for the validation of gene aberrations identified in genomic studies. It promises to enhance our understanding of lung cancer oncogenesis.

• Author: Xiangdong Wang; Yong Zhang; Carol Nilsson; Frode Berven; Per E. Andrén; Elisabet Carlsohn; Peter Horvatovich; Johan Malm; Manuel Fuentes; Ákos Végvári; Charlotte Welinder; Thomas Fehniger; Melinda Rezeli; Goutham Edula; Toshihide Nishimura; György Marko-Varga
• Department/s: Department of Clinical Sciences, Lund; Clinical Chemistry, Malmö; Department of Biomedical Engineering; Clinical Protein Science and Imaging
• Publishing year: 2015
• Language: English
• Pages: 217-226
• Publication/Series: Cancer and Metastasis Reviews
• Volume: 34
• Issue: 2
• Links: http://dx.doi.org/10.1007/s10555-015-9556-2
• Document type: Journal article review
• Publisher: Springer
• Topic: Cancer and Oncology
• Status: Published
• Research group: Clinical Chemistry, Malmö; Clinical Protein Science and Imaging
• ISBN/ISSN/Other: ISSN: 0167-7659