The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Changes of the uterine proteoglycan distribution at term pregnancy and during labour

På svenska

Author

Summary, in English

Objective: To characterise uterine proteoglycans and changes therein during pregnancy and labour. Study Design: Uterine samples were collected from 6 non-pregnant, 10 term-pregnant and from 10 women in active tabour. The proteoglycans were extracted by 4 M guanidine hydrochloride and precipitated with Alcian Blue. They were separated by electrophoresis and identified by Western blotting. Results: Decorin was the dominating proteoalycan and smaller amounts of biglycan was found. A considerable amount of heparan sulphate proteoglycans wag also detected. Decorin and biglycan decreased by 40% until term. The amount of heparan sulphate proteoglycans increased by 46% during active labour. Conclusion: Our data indicate that a considerable remodelling of the uterine connective tissue occurs during pregnancy and labour. The decrease of decorin and biglycan and the increase of heparan sulphate proteoglycans may be important for normal myometrial contractions during tabour. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Department/s

  • Matrix Biology

Publishing year

2002

Language

English

Pages

146-151

Publication/Series

European Journal of Obstetrics, Gynecology, and Reproductive Biology

Volume

100

Issue

2

Document type

Journal article

Publisher

Elsevier

Topic

  • Obstetrics, Gynecology and Reproductive Medicine

Keywords

  • uterus
  • proteoglycans
  • labour
  • pregnancy

Status

Published

Research group

  • Matrix Biology

ISBN/ISSN/Other

  • ISSN: 0301-2115