MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant.

Summary, in English

New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and adult brain. In this study we found that microRNA-124 (miR-124) dictates postnatal neurogenesis in the mouse subventricular zone. Using a transgenic reporter mouse we show that miR-124 expression is initiated in the rapid amplifying progenitors and remains expressed in the resulting neurons. When we stably inhibited miR-124 in vivo, neurogenesis was blocked, leading to the appearance of ectopic cells with astrocyte characteristics in the olfactory bulb. Conversely, when we overexpressed miR-124, neural stem cells were not maintained in the subventricular zone and neurogenesis was lost. In summary, our results demonstrate that miR-124 is a neuronal fate determinant in the subventricular zone.

• Author: Malin Åkerblom; Rohit Sachdeva; Isabelle Barde; Sonia Verp; Bernhard Gentner; Didier Trono; Johan Jakobsson
• Department/s: Molecular Neurogenetics; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publishing year: 2012
• Language: English
• Pages: 8879-8889
• Publication/Series: The Journal of Neuroscience : the official journal of the Society for Neuroscience
• Volume: 32
• Issue: 26
• Full text: - 5 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/22745489?dopt=Abstract; http://dx.doi.org/10.1523/JNEUROSCI.0558-12.2012
• Document type: Journal article
• Publisher: Society for Neuroscience
• Topic: Neurosciences
• Status: Published
• Research group: Molecular Neurogenetics
• ISBN/ISSN/Other: ISSN: 1529-2401