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Tissue reactions to polyethylene implants with different surface topography

På svenska

Author

Summary, in English

This study investigates the importance of implant surface topography on soft tissue response. The tissue response in the rat abdominal wall to discs of low density polyethylene with smooth to coarse surfaces was evaluated after one, six or 12 weeks. Capsule thickness and immunohistochemical quantification of monocytes-macrophages were used as measures. The macrophage specific antibody ED1 was used for identification of newly recruited macrophages and the ED2 antibody for the mature tissue macrophages. The smoother surfaces gave a thicker capsule than the rougher surfaces, and at one week also larger total numbers of cells and ED1 positive macrophages at interface. The capsule thickness increased over time for the smooth and intermediate surface topographies. In contrast, the cell numbers generally decreased over time. In conclusion, a coarse surface elicited lesser tissue reaction compared with a smooth surface.

Department/s

Publishing year

1999

Language

English

Pages

75-82

Publication/Series

Journal of Materials Science: Materials in Medicine

Volume

10

Issue

2

Document type

Journal article

Publisher

Springer

Topic

  • Medical Materials

Status

Published

Research group

  • Neural Interfaces

ISBN/ISSN/Other

  • ISSN: 1573-4838