The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

High frequency of primary hyperaldosteronism among hypertensive patients from a primary care area in Sweden

På svenska

Author

Summary, in English

Objective. To search for primary hyperaldosteronism (PHA) among previously known hypertensive patients in primary care, using the aldosterone/renin ratio (ARR), and to evaluate clinical and biochemical characteristics in patients with high or normal ratio. Design. Patient survey study. Setting and subjects. The study population was recruited by written invitation among hypertensive patients in two primary care areas in Sweden. A total of 200 patients met the criteria and were included in the study. Main outcome measures. The ARR was calculated from serum aldosterone and plasma renin concentrations. The cut-off level for ARR was set to 100, as confirmed in 28 healthy subjects. Patients with increased ARR were considered for a confirmatory test, using the fludrocortisone suppression test. Results. Of 200 patients, 50 patients had ARR >100; 26 patients were further evaluated by fludrocortisone suppression test. Seventeen of these patients had an incomplete aldosterone inhibition. Conclusion. In total 17 of 200 evaluated patients (8.5%) had an incomplete suppression with fludrocortisone. This confirms previous reports on a high frequency of PHA. No significant biochemical or clinical differences were found among hypertensive patients with PHA compared with the whole sample.

Publishing year

2006

Language

English

Pages

154-159

Publication/Series

Scandinavian Journal of Primary Health Care

Volume

24

Issue

3

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Health Care Service and Management, Health Policy and Services and Health Economy

Keywords

  • primary hyperaldosteronism
  • hypertension
  • family practice
  • aldosterone
  • aldosterone to renin ratio
  • renin

Status

Published

Research group

  • Family Medicine and Community Medicine

ISBN/ISSN/Other

  • ISSN: 0281-3432