Real exposure to pig pancreatic juice and bile inhibit exocrine pancreatic secretion in pigs
Author
Summary, in English
The mechanisms involved in the down regulation of the exocrine pancreas are still not fully elucidated. The purpose of the present study was to examine the effect of duodenal and ileal exposure to pancreatic enzymes and bile on pancreatic secretion. Experiments were performed with pigs fitted with pancreatic duct, ileal and jugular vein catheters, and duodenal T-shaped cannula. A negative feedback regulation of pancreatic secretion was found for both duodenal and ileal delivery of pancreatic juice. Pancreatic secretion was unaffected by duodenal delivery of bile and bile salts, while ileal delivery of bile and bile salts lowered it. On the other hand, pancreatic secretion was increased by duodenal loading of commercial non- or activated pancreatic enzyme preparations, thus probably recognised as dietary protein. Plasma cholecystokinin (CCK) level was lowered only by duodenal delivery of pancreatic juice. In conclusion, the results prove the existence of negative feedback mechanism regulating pancreatic secretion dependent on the presence of pure pancreatic juice or bile at the ileal level. The mechanism at the duodenal level is exclusively sensitive to pure pancreatic juice. (c) 2007 Elsevier B.V All rights reserved.
Department/s
Publishing year
2007
Language
English
Pages
53-56
Publication/Series
Livestock Science
Volume
108
Issue
1-3
Document type
Journal article
Publisher
Elsevier
Topic
- Zoology
Keywords
- ileum
- pancreatic secretion
- duodenum
- ileal brake
Status
Published
ISBN/ISSN/Other
- ISSN: 1871-1413