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Total Synthesis of Transtaganolide E and F: Insight in the Biosynthesis of the Transtaganolides

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Author

  • Rikard Larsson
  • Hans W. Scheeren
  • Rene W. M. Aben
  • Martin H Johansson
  • Olov Sterner

Summary, in English

A total synthesis of transtaganolide E and F, proposed intermediates in the biosynthesis of the potent transtaganolides, including an Ireland-Claisen rearrangement and a high-pressure intramolecular Diels-Alder cycloaddition reaction of an unactivated 2-pyrone derivative, is reported. The implication of the results to the proposed transtaganolides biosynthesis is discussed.

Publishing year

2013

Language

English

Pages

6955-6960

Publication/Series

European Journal of Organic Chemistry

Volume

2013

Issue

30

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Chemical Sciences

Keywords

  • Transtaganolides
  • Rearrangement
  • Cycloaddition
  • Biosynthesis
  • Natural
  • products

Status

Published

ISBN/ISSN/Other

  • ISSN: 1434-193X