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High Survivin Levels Predict Poor Clinical Response to Infliximab Treatment in Patients with Rheumatoid Arthritis

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Author

  • Anniella Isgren
  • Kristina Forslind
  • Malin Erlandsson
  • Carl Axelsson
  • Sofia Andersson
  • Anneli Lund
  • Maria Bokarewa

Summary, in English

Objective: To evaluate if the measurement of survivin in the blood of patients with rheumatoid arthritis (RA) undergoing infliximab treatment has predictive value for treatment response. Methods: The study included 87 consecutive RA patients (age 24-89 years, disease duration 18-526 months) treated with regular infusions of influximab. Survivin levels were measured by enzyme-linked immunosorbent assay and evaluated in relation to the total dose of infliximab, disease activity (DAS28), response to infliximab treatment (change in DAS28 > 1.2), and radiographic damage (vdH-Sharp score). Results: Thirty-seven percent of patients were survivin-positive (survivin > 0.9 ng/mL) and showed severe radiographic damage at the start of infliximab treatment compared with survivin-negative (P = 0.027). Patients with high survivin levels were unlikely to respond to infliximab treatment (OR 4.02 [1.22-14.61], P = 0.022) and achieve remission (OR 4.32[1.01-30.11], P = 0.048) compared with patients with low survivin levels. Conclusions: High survivin levels are associated with severe radiographic damage at the start of treatment and a poor response to infliximab. Survivin measurement should be considered an additional tool for aiding the selection and follow-up of antirheumatic treatment. (C) 2012 Elsevier Inc. All rights reserved. Semin Arthritis Rheum 41:652-657

Publishing year

2012

Language

English

Pages

652-657

Publication/Series

Seminars in Arthritis and Rheumatism

Volume

41

Issue

5

Document type

Journal article review

Publisher

W.B. Saunders

Topic

  • Rheumatology and Autoimmunity

Keywords

  • rheumatoid arthritis
  • infliximab
  • surviving
  • treatment

Status

Published

ISBN/ISSN/Other

  • ISSN: 0049-0172