A novel treatment approach for paediatric Gorham-Stout syndrome with chylothorax

Summary, in English

Aim: To expand the treatment options in paediatric Gorham-Stout syndrome (GSS) when conventional therapy is ineffective. Method: Two children with biopsy confirmed GSS, a rare disorder with progressive lymphangiomatosis, were treated with a combination of interferon-alpha-2b, low anticoagulant, low molecular weight heparin, radiotherapy and surgery. Results: The combined therapy resolved the symptoms in the acute phase, and both patients have since been free of symptoms for >2 years. Conclusion: The successful addition of a low anticoagulant, low molecular weight heparin ( tafoxiparin) to the treatment protocol in two paediatric cases of the GSS may justify the use of this approach in similar cases.

• Author: Nicholas Brodszki; John-Kalle Länsberg; Michael Dictor; Erik Gyllstedt; Sven-Börje Ewers; Marcus Larsson; Erik Eklund
• Department/s: Paediatrics (Lund); Tumor microenvironment; Thoracic Surgery; Breastcancer-genetics; Matrix Biology
• Publishing year: 2011
• Language: English
• Pages: 1448-1453
• Publication/Series: Acta Pædiatrica
• Volume: 100
• Issue: 11
• Links: http://www.ncbi.nlm.nih.gov/pubmed/21605166?dopt=Abstract; http://dx.doi.org/10.1111/j.1651-2227.2011.02361.x
• Document type: Journal article
• Publisher: Wiley-Blackwell
• Topic: Cancer and Oncology
• Keywords: Acute respiratory failure; Alpha-interferon therapy; Heparin
• Status: Published
• Research group: Matrix Biology
• ISBN/ISSN/Other: ISSN: 1651-2227