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Characterization of the gene for prostate-specific antigen, a human glandular kallikrein

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Author

Summary, in English

The gene for the human glandular kallikrein, prostate-specific antigen, has been cloned. The sequence of 7130 nucleotides encompassing the gene and 633 bp of 5' and 639 bp of 3' flanking DNA has been determined. The translation initiation site was slightly heterogeneous, yielding 5' non-translated leader sequences of 41 and 35 bp. The gene is divided into five exons, with introns located at positions identical with those found in other glandular kallikrein genes. The nucleotide sequence is very similar to that of the human kallikrein gene hGK-1, with 76 to 93% of the nucleotides being identical in the exons and 76 to 87% in the introns. The similarity also extends approximately 200 bp into the sequence flanking the 5' end of hGK-1 and several other, both human and rodent, glandular kallikrein genes.

Publishing year

1989

Language

English

Pages

9-1151

Publication/Series

Biochem Biophys Res Commun

Volume

161

Issue

3

Document type

Journal article

Publisher

Elsevier

Topic

  • Medicinal Chemistry

Keywords

  • Prostate-Specific Antigen
  • Prostate/*immunology
  • Molecular Sequence Data
  • Male
  • Kallikreins/*genetics
  • Introns
  • Humans
  • *Genes
  • Exons
  • Molecular
  • Cloning
  • Base Sequence
  • Amino Acid Sequence
  • Neoplasm/*genetics
  • Antigens
  • RNA Caps/genetics
  • Repetitive Sequences
  • Nucleic Acid
  • Research Support
  • Non-U.S. Gov't
  • Restriction Mapping
  • Tissue Kallikreins

Status

Published

Research group

  • Clinical Chemistry, Malmö