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Optimizing nanovial outlet designs for improved solid-phase extraction in the integrated selective enrichment target-ISET.

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Author

Summary, in English

The integrated selective enrichment target is a microfluidic platform for SPE sample preparation with integrated nanocolumns, which simultaneously offers direct MALDI MS read-out. Here, we present a study on the importance of different nanocolumn outlet hole geometries and hole areas in relation to MS signal intensity and reproducibility. A design solution that provides the flow characteristics required for robust sample preparation using automated liquid handling is reported.

Publishing year

2012

Language

English

Pages

3143-3150

Publication/Series

Electrophoresis

Volume

33

Issue

21

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Medical Engineering

Status

Published

ISBN/ISSN/Other

  • ISSN: 0173-0835