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Immunocytochemical demonstration of estrogen receptor beta in human periodontal ligament cells.

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Author

Summary, in English

Two transcription associated estrogen receptor (ER) subtypes have been identified and named ERα and ERβ. In the present study we investigate the expression of these ER subtypes in cultured human periodontal ligament (PDL) cells by immunocytochemistry. ERβ immunoreactivity was observed in the nuclei of about 40% of the PDL cells, while no ERα immunoreactivity was detected. In human breast cancer MCF-7 cells, serving as positive controls, both ERα and ERβ immunoreactivities were demonstrated. No immunoreactivity was observed after omission of the primary antibodies. This study suggests that estrogen acts on gene transcription preferentially via ERβ in human PDL cells.

Department/s

Publishing year

2004

Language

English

Pages

85-88

Publication/Series

Archives of Oral Biology

Volume

49

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Cell and Molecular Biology
  • Gastroenterology and Hepatology
  • Physiology

Keywords

  • Periodontal ligament cells
  • Estrogen receptors
  • Immunocytochemistry

Status

Published

Research group

  • Vascular Physiology
  • Neurogastroenterology

ISBN/ISSN/Other

  • ISSN: 1879-1506