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Molecular cloning of human prostate specific antigen cDNA

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Author

Summary, in English

A lambda gt11 clone encoding prostate specific antigen has been isolated from a human prostate cDNA library. The cDNA insert of 1415 nucleotides hybridizes specifically to a prostate mRNA species of 1.5 kb. The nucleotide sequence codes for part of a signal peptide, a short propiece and the mature protein of 237 amino acid residues. The Mr for the non-glycosylated protein was 26,089. One potential site for N-linked carbohydrate attachment was identified. The primary structure shows extensive homology with proteases of the kallikrein family.

Publishing year

1987

Language

English

Pages

22-317

Publication/Series

FEBS Letters

Volume

214

Issue

2

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Medicinal Chemistry

Keywords

  • Non-U.S. Gov't
  • Research Support
  • Prostate-Specific Antigen
  • Prostate/immunology
  • Male
  • Humans
  • DNA/*genetics
  • Molecular
  • Cloning
  • Base Sequence
  • Amino Acid Sequence
  • Antigens/*genetics

Status

Published

Research group

  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1873-3468