Dissecting the potential molecular mechanisms underlying alpha-synuclein cell-to-cell transfer in Parkinson's disease.

Summary, in English

Alpha-synuclein (alpha-syn) aggregation is central to neuropathological changes in Parkinson's disease. The aggregates spread within the central nervous system according to a very predictable pattern. A prion-like transmission of alpha-syn aggregates has been recently proposed to explain this propagation pattern. First, we review the growing evidence for such a mechanism. This process is likely to occur in three consecutive steps: (i) exit of alpha-syn template from the donor cell, (ii) entry to the recipient cell and (iii) initiation of the nucleation. In a second part, we discuss the possible underlying mechanisms for each of these steps, based on our current knowledge about how cells handle alpha-syn but also other proteins involved in neurodegenerative diseases with a prion-like propagation. Finally, we discuss which molecular species of alpha-syn (monomer, oligomer, fibril) could be the seeding-competent species and whether this seeding process could be a common mechanism in neurodegenerative diseases.

• Author: Elodie Angot; Patrik Brundin
• Department/s: Department of Experimental Medical Science
• Publishing year: 2009
• Language: English
• Pages: 143-147
• Publication/Series: Parkinsonism & Related Disorders
• Volume: 15 Suppl 3
• Links: http://www.ncbi.nlm.nih.gov/pubmed/20082977?dopt=Abstract; http://dx.doi.org/10.1016/S1353-8020(09)70802-8
• Document type: Journal article
• Publisher: Elsevier
• Topic: Neurology
• Status: Published
• ISBN/ISSN/Other: ISSN: 1873-5126