Building authentic midbrain dopaminergic neurons from stem cells - lessons from development
Author
Summary, in English
The challenge with controlling the differentiation of human pluripotent cells to generate functional dopaminergic neurons for the treatment of Parkinson's disease has undergone significant progress in recent years. Here, we summarize the differences between newer and older protocols for generating midbrain dopaminergic neurons from human pluripotent stem cells, and we highlight the importance of following developmental pathways during differentiation. The field has now developed to a point where it is timely to take human pluripotent stem cells one step closer to clinical use, and cell criteria to be fulfilled for such developments are outlined in this review.
Department/s
Publishing year
2012
Language
English
Pages
314-319
Publication/Series
Translational Neuroscience
Volume
3
Issue
4
Document type
Journal article
Publisher
Versita
Topic
- Neurology
Keywords
- Stem cells
- Dopaminergic neurons
- Differentiation
- Development
Status
Published
Research group
- Developmental and Regenerative Neurobiology
ISBN/ISSN/Other
- ISSN: 2081-6936