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Synthesis of podoscyphic acid

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Author

Summary, in English

Podoscyphic acid 1, a fungal metabolite inhibiting RNA-directed DNA polymerises, was synthesised in four steps starting from dodecanal. The concluding ester hydrolysis of 4 was not feasible with chemical reagents, only enzymatic hydrolysis was mild enough to release the highly reactive natural product in good yields. (C) 2002 Elsevier Science Ltd. All rights reserved.

Publishing year

2002

Language

English

Pages

891-893

Publication/Series

Tetrahedron Letters

Volume

43

Issue

5

Document type

Journal article

Publisher

Elsevier

Topic

  • Organic Chemistry

Keywords

  • enzymatic hydrolysis
  • podoscyphic acid
  • synthesis lipase

Status

Published

ISBN/ISSN/Other

  • ISSN: 0040-4039