The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Skeletal muscle telomere length is not impaired in healthy physically active old women and men

På svenska

Author

Summary, in English

We have previously shown that the number of satellite cells is lower in old than young men and women. The aim of this study was to further explore the effects of aging on the regenerative potential of skeletal muscle in 16 young and 26 old men and women with comparable physical activity level (young, 25 +/- 4 years; old, 75 +/- 4 years). Mean and minimum telomere lengths were determined using Southern blot analyses on biopsies obtained from the tibialis anterior muscle. There were no significant age or gender effects on mean and minimal telomeric lengths, suggesting that the replicative potential in the remaining satellite cells in the tibialis anterior muscle is not impaired with increasing age and the existence of in vivo regulatory mechanisms allowing the maintenance of telomere length. These results imply that moderate physical activity regularly performed by old subjects is not associated with accelerated telomere loss.

Department/s

Publishing year

2008

Language

English

Pages

467-472

Publication/Series

Muscle and Nerve

Volume

37

Issue

4

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Neurology
  • Surgery

Keywords

  • telomere
  • satellite cell
  • regeneration
  • aging
  • exercise

Status

Published

ISBN/ISSN/Other

  • ISSN: 0148-639X