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The calpain inhibitor VI prevents apoptosis of adult motor neurons

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Author

  • HamidReza Momeni
  • Martin Kanje

Summary, in English

Motor neuron cell death was studied in organotypic cultures of adult spinal cord slices from the mouse. Six hours after excision, many motor neuron nuclei displayed apoptotic features including nuclear and chromatin condensation. At this time point, many motor neurons also exhibited immunoreactivity to calpain II. Both the calpain inhibitor VI and ethyleneglycol-bis(beta-aminoethyl ether) N,N,N',N'-tetraacetic acid (EGTA) prevented the appearance of apoptotic nuclei whereas the pan caspase inhibitor Z-VAD.fmk had no effect. The results suggest that calpain is required for apoptosis of motor neurons and that this type of apoptosis is independent of caspase activation.

Publishing year

2005

Language

English

Pages

1065-1068

Publication/Series

NeuroReport

Volume

16

Issue

10

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Neurosciences

Keywords

  • culture
  • organ
  • motor neurons
  • caspase
  • calpain inhibitor
  • apoptosis
  • calpain
  • spinal cord

Status

Published

ISBN/ISSN/Other

  • ISSN: 1473-558X