Two new biologically active cyclopentenones from Dasyseyphus sp A47-98

Summary, in English

Two new biological active cyclopentenones VM 4798-1a (1a) and VM 4798-1b (1b) were obtained as a 3 : 1 inseparable mixture from fermentations of Dasyscyphus sp. A47-98. The mixture of the two isomers showed cytotoxic and weak antibacterial and antifungal properties. VM 4898-1 (2-hydroxy-3,4-dimethyl-2-cyclopenten-1-one, 4), produced by another Dasyscyphus sp. showed no significant biological activity. The structures were elucidated by NMR techniques.

• Author: V Mierau; Olov Sterner; T Anke
• Department/s: Centre for Analysis and Synthesis
• Publishing year: 2004
• Language: English
• Pages: 311-315
• Publication/Series: Journal of Antibiotics
• Volume: 57
• Issue: 5
• Links: http://www.antibiotics.or.jp/journal/contents/vol-57/full_text/57-5/ja57_0311.pdf; http://www.antibiotics.or.jp/journal/contents/vol-57/57-5_contents.htm
• Document type: Journal article
• Publisher: Japan Antibiotics Research Association
• Topic: Organic Chemistry
• Status: Published
• ISBN/ISSN/Other: ISSN: 0021-8820